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KMID : 0364920060310030115
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Journal of Radiation Protection and Research
2006 Volume.31 No. 3 p.115 ~ p.122
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Radioprotective Effect of Extracts from Plants Indigenous to Korea
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Kang Kyoung-Ah
Zhang Rui
Chae Sung-Wook
Piao Mei Jing
Shin Tae-Kyun
Lee Nam-Ho
Park Jae-Woo
Hyun Jin-Won
Zhang Rui
Chae Sung-Wook
Piao Mei Jing
Shin Tae-Kyun
Lee Nam-Ho
Park Jae-Woo
Hyun Jin-Won
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Abstract
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We have screened the cytoprotective effect on $\gamma$-ray radiation induced oxidative stress from eighteen Korean plant extracts. Querus salicina, Clerodendron trichotomum, Lamium amplexicaule, Lozoste lancifolia and Malus baccata were found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). As a result, extracts of these plants reduced cell death of Chinese hamster lung fibroblast (V79-4) cells induced by $H_2O_2$ treatment. In addition, these extracts protected cell death of V79-4 cells damaged by $\gamma$-ray radiation. In addition, these extracts scavenged ROS generated by radiation. Taken together, the results suggest that Quercus salicina, Clerodendron trichotomum, Lamium amplexicaule, Lozoste lancifolia and Malus baccata protect V79-4 cells against oxidative damage by radiation through scavenging ROS.
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KEYWORD
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${\gamma}$-ray radiation, oxidative stress, reactive oxygen species
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